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‘Of course, that's about suitable. I look for a Bodily idea of biological programs inside of a bottom-up way. I feel you could potentially distinguish three strains of study in my group at the moment. The initial problems chromosome structure: How can you have a metre-extensive DNA polymer folded and organised in such a microscopic cell? We've got formulated visualisation techniques that permit us to review how, such as, SMC proteins loop DNA (video on Youtube) as a way to Make up chromosomes.

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[Laughs] ‘It was undoubtedly a fantastic possibility! At some time, I was properly informed that it could go Improper Which I could come to be a lot less profitable, but I just disregarded that. Curiosity has normally been my strongest driving drive. And luckily it all labored out.’

Our operate was promptly adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 posted their conclusions on transistors made from single- and multi-walled carbon nanotubes in Applied Physics Letters.

2012, discovery that nucleoid occlusion underlies the precision of bacterial mobile division; and initially ever review ceesdekker.net in the dynamics DNA supercoils and the invention of supercoil hopping

Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes

‘Initially we checked out Organic systems using a Actual physical view and acted on The premise of the tools we knew. It took a several years in advance of we started Functioning additional on the massive Organic problems. I then started to phone it nanobiology, a time period that didn't exist at the time.

Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.

The rotors harness Vitality from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical likely gradient within the nanopore, which happen to be recognized through a salt gradient or used voltage, respectively. These artificial nanoengines self-Manage and run autonomously in physiological circumstances, suggesting tips on how to constructing Electrical power-transducing motors at nanoscale interfaces.

Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-producing method

‘The concept there is such a issue as a starting, a giant bang, is already an interesting signpost to look at that there was a creator. But more typically, and on The idea of pure rationality, I also get there in a Christian interpretation of truth. An atheistic worldview is really a naturalistic worldview: basically, there are actually only atoms and pure forces that we could evaluate.

2006, first demonstration of molecular sorting within a lab with a chip utilizing biomotors; discovery of nanobubbles in reliable-condition nanopores; and to start with estimate of electrokinetic Power conversion in the nanofluidic channel

Visualization of unstained DNA nanostructures with Innovative in-aim transmission electron microscopy methods

The biophysicist from Delft – who has long been One of the more cited experts from the Netherlands For several years – normally takes his accountability to lead for the explanation and popularisation of his do the job for the border of physics and biology particularly significantly and frequently seems from the media; if not to discuss his function, then about the connection involving science and his Christian faith.